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eshelmen-institute-innovationOn Dec. 3, 2014, Carolina announced a $100 million commitment from Fred Eshelman to the Eshelman School of Pharmacy.

The commitment is the largest from an individual in UNC history and the largest ever to a U.S. pharmacy school. It created the Eshelman Institute for Innovation to pursue high-risk, high-reward ideas that advance innovation in pharmacy education, research and health care.

Two times per year, the institute will seek proposal submissions from the Eshelman School of Pharmacy’s faculty, staff and students for big ideas and innovations that have measurable impact and lead to transformative change in:

  • Basic and applied research in the pharmaceutical sciences
  • Health-care quality, practice and policy
  • Health-sciences education and educational research
  • Business processes and practices

For the inaugural cycle, 24 of 53 submitted proposals were funded, with a total of nearly $9.4 million awarded. They were:

Tier 1: Up to a total of $50,000

  • Delesha Carpenter, Division of Pharmaceutical Outcomes and Policy
    Non-invasive Technology to Continuously Monitor and Improve Patient Medication Adherence
  • Alexander Golbraikh, Division of Chemical Biology and Medicinal Chemistry
    Large-Scale Polypharmacology Modeling Using Deep Learning
  • Shawn Hingtgen, Division of Molecular Pharmaceutics
    Cytotoxic Stem Cell Therapy for Pediatric Brain Cancer
  • Weigang Huang, Division of Chemical Biology and Medicinal Chemistry
    Profiling Cellular Phosphoinositide Metabolism for Disease Diagnosis
  • Robert Hughes, Division of Chemical Biology and Medicinal Chemistry
    Optogenetics, Cytoskeletal Dysregulation, and Disease
  • Alexander Kabanov, Division of Molecular Pharmaceutics
    Carolina Nanoformulation Workshop
  • Alexander Kabanov, Division of Molecular Pharmaceutics/Center for Nanotechnology in Drug Delivery
    RECOPE: Reverse Conceptual Product Engineering
  • Dmitri Kireev, Center for Integrative Chemical Biology and Drug Discovery
    Molecular Simulations of Ultra-Large Biological Systems
  • Samuel Lai, Division of Molecular Pharmaceutics
    Shoebox-Sized Plasmapheresis Machine for Cheap & Rapid Generation of Convalescent Serum in Africa
  • Rihe Liu, Division of Chemical Biology and Medicinal Chemistry
    Decipher a Highly Specific Biomarker for Targeted Treatment of Pancreatic Cancer
  • Craig Lee, Division of Pharmacotherapy and Experimental Therapeutics
    Solving the Mystery of Highly Variable Drug Disposition in Pregnant Women: Are Unique Hepatic Drug Metabolizing Enzymes Activated During Pregnancy?
  • Xin Ming, Division of Molecular Pharmaceutics
    P-Glycoprotein Targeted Antibody Conjugates for Combating Chemoresistant Tumors
  • Bill Zamboni, Division of Pharmacotherapy and Experimental Therapeutics
    Enhancing Tumor Delivery of Nanoparticle Anticancer Agents Using Microbeam Radiation Therapy

Tier 2: Up to a total of $200,000

  • Emily Hull-Ryde, Division of Chemical Biology and Medicinal Chemistry/Center for Integrative Chemical Biology and Drug Discovery
    Controlling the Mucus That Kills Pulmonary Patients
  • Samuel Lai, Division of Molecular Pharmaceutics
    Carolina E(I) Lab: A Multidisciplinary, Entrepreneurial Experience in Transforming Bold Ideas Into Successful Ventures
  • Jacqui McLaughlin, Division of Practice Advancement and Clinical Education
    Transforming Data into Knowledge: Fostering Institutional Effectiveness through Real-Time Analytics

Tier 3: Up to a total of $750,000

  • Shawn Hingtgen, Division of Molecular Pharmaceutics
    Transdifferentiation: A Novel Approach to Personalized Cancer Therapy
  • Leaf Huang, Division of Molecular Pharmaceutics
    Priming the Liver to Resist Cancer Metastasis
  • Samuel Lai, Division of Molecular Pharmaceutics
    Engineered Antibodies With Carefully Tuned Mucin-Affinity for Enhanced Mucosal Protection
  • David Lawrence, Division of Chemical Biology and Medicinal Chemistry
    Light-Triggered Launching of Anti-Glioblastoma Therapeutics From Cellular Silos
  • Jian Liu, Division of Chemical Biology and Medicinal Chemistry
    Developing Carbohydrate-Based Medicines
  • Mary McClurg, Division of Practice Advancement and Clinical Education
    Innovations in Practice Transformation: Advancing Medication Optimization in Primary Care

Tier 4: Up to a total of $2 million

  • Alexander Tropsha, Division of Chemical Biology and Medicinal Chemistry
    Center for Innovation in Pharmacy Simulation (CIPS)
  • Tim Willson, Structural Genomics Consortium – UNC
    The SCG-UNC: A Center for Open and Collaborative Target Discovery
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